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Phosphoramidon could significantly reduce the mitogenic effect of ECCM. Phosphoramidon可明顯地抑制 ECCM對 SMC的增殖作用。
ECCM, ECCM conditioned in the presence of phosphoramidon, SMCCM and ET 1 were added individually to the cultures. 結果 ECCM和 ET- 1可明顯促進 SMC的增殖 ;竝呈現劑量依賴性 .
Methods:EC and SMC were isolated from rabbit aortas and cultured. The conditioned medium(CM) of EC and SMC were harvested. ECCM,ECCM conditioned in the presence of Phosphoramidon,SMCCM and ET-1 were added individually to the cultures. 方法 :EC和 SMC均來源於兔主動脈 ,在獲得了 EC和SMC的條件培養基 (CM)後 ,分別用兩者以及 ET- 1進行實騐 ,細胞的增殖率通過 3H摻入法進行測定。